The Definitive Guide On Fasting, Autophagy, And Caloric Restriction (#GotBitcoin?)
Just a quick update to let you guys know our little background project of harvesting a useful trove of information from older interviews continues unabated!
Here’s the full playlist for the collection recently pulled from the interview with Dr. Guido Kroemer…
- What is autophagy? Degradation, recycling, and a beneficial response to stress | Guido Kroemer
- Minimum fasting length required for autophagy | Guido Kroemer
- Caloric Restriction Mimetics in Aging, Improved Cancer Chemotherapy, Autophagy Anti-Obesity Effect
- Autophagy expert: Dr. Guido Kroemer’s personal take on fasting, eating and other lifestyle habits
- Can limiting protein intake (or other selective nutrient depletion) induce autophagy?
- Periodic fasting has the same longevity benefit as caloric restriction (and without emaciation)
- Deprivation of nutrients (starvation) and other signals that play a key role in inducing autophagy
- Exercise-induced autophagy and its role in preventing diabetes | Guido Kroemer
- How the cell prioritizes and targets organelles and protein aggregates for degradation by autophagy
- Autophagy and cancer: a crucial role in immunosurveillance and chemotherapeutic treatment
- Fasting associated with sickness behavior critical to surviving bacterial infection | Guido Kroemer
- Mitophagy: a signal for mitochondrial biogenesis, metabolic adaptation, and cellular differentiation
- Increasing general autophagy as a treatment for neurodegenerative diseases like Parkinson’s Disease
- Does coffee induce autophagy? | Guido Kroemer
As many of you know, autophagy is an important part of the fasting discussion, so these will ultimately be making up a larger fasting playlist that covers everything fasting-related from FoundMyFitness all in one place! Coming soon.
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Perciavalle Patrick has a Ph.D. in biomedical science from the University of Tennessee Health Science Center, Memphis TN and St. Jude Children’s Research Hospital, Memphis TN. She also has a Bachelor’s of Science degree in biochemistry/chemistry from the University of California, San Diego. She has done extensive research on aging, cancer, and nutrition. She did her graduate research at St. Jude Children’s Research Hospital where she investigated the link between mitochondrial metabolism, apoptosis, and cancer. Her groundbreaking work discovered that a protein that is critical for cell survival has two distinct mitochondrial localizations with disparate functions, linking its anti-apoptotic role to a previously unrecognized role in mitochondrial respiration and maintenance of mitochondrial structure. Her dissertation findings were published in the 2012 issue of Nature Cell Biology.
Dr. Patrick trained as a postdoctoral fellow at Children’s Hospital Oakland Research Institute with Dr. Bruce Ames. She investigated the effects of micronutrient (vitamins and minerals) inadequacies on metabolism, inflammation, DNA damage, and aging and whether supplementation can reverse the damage. In addition, she also investigated the role of vitamin D in brain function, behavior, and other physiological functions and has published papers in FASEB on how vitamin D regulates serotonin synthesis and how this relates to autism and other neuropsychiatric disorders.
Dr. Patrick has also done research on aging at the Salk Institute for Biological Sciences. At the Salk, she investigated what role insulin signaling played in protein misfolding, which is commonly found in neurodegenerative diseases such as Alzheimer’s disease.
She frequently engages the public on topics including the role micronutrient deficiencies play in diseases of aging, the role of genetics in determining the effects of nutrients on a person’s health status, benefits of exposing the body to hormetic stressors, such as through exercise, fasting, sauna use or heat stress, or various forms of cold exposure, and the importance of mindfulness, stress reduction, and sleep. It is Dr. Patrick’s goal to challenge the status quo and encourage the wider public to think about health and longevity using a proactive, preventative approach.
* Vitamin D and the Omega-3 Fatty Acids Control Serotonin Synthesis and Action, Part 2: Relevance for ADHD, Bipolar, Schizophrenia, and Impulsive Behavior FASEB Journal
* Vitamin D Hormone Regulates Serotonin Synthesis. Part 1: Relevance for Autism FASEB Journal
* Requirement for Anti-Apoptotic MCL-1 in the Survival of BCR-ABL B-Lineage Acute Lymphoblastic Leukemia Blood
* Delving Deeper: MCL-1′s Contribution to Normal and Cancer Biology Trends in Cell Biology
* Anti-Apoptotic MCL-1 Localizes to the Mitochondrial Matrix and Couples Mitochondrial Fusion to Respiration Nature Cell Biology
* Ubiquitin-Independent Degradation of Anti-Apoptotic MCL-1 Molecular and Cellular Biology
* Opposing Activities Protect Against Age-Onset Proteotoxicity Science